Comparison of immune responses to different vaccines, including Novavax trial (NN) as well as Pfizer (PP), Moderna (MM), and J&J (J) (two doses each except one dose for J&J). Also, comparison to infected (I) for some aspects.
https://www.biorxiv.org/content/10.1101/2022.03.18.484953v1.full
Approximate rankings from graphs:
| Aspect of immune response | Response to different vaccines |
|---|---|
| Spike IgG antibodies | MM, PP > I > NN > J |
| RBD IgG antibodies | MM, PP > NN > I, J |
| Pseudovirus neutralization | MM > PP, NN > I, J |
| CD4+ T-cells | MM, NN > PP > J > I |
| CD4+ T-cells (cTfh) | NN > MM, PP > I > J |
| CD8+ T-cells | J, MM > PP > NN |
| Spike memory B-cells | PP, MM > J > NN |
| RBD memory B-cells | MM > PP > J, NN |