Research paper on the effect on immune response against different variants due to infection by different variants on thrice Pfizer-vaccinated people:
https://www.science.org/doi/10.1126/science.abq1841
Some interesting findings:
- Omicron infection in those without prior infection noticeably boosted antibody response compared to no infection or infection with the ancestral virus.
- This boosted antibody response was seen against the ancestral virus, Alpha, Beta, Gamma, Delta, and itself.
- However, the antibody response against itself was weaker than against other variants.
- Omicron infection in those who previously had infection with the ancestral virus did not boost antibody response significantly. “Original antigenic sin” perhaps?