<p>... Well, first off, I'm a senior who will be entering the ISTS. </p>
<p>While my school does have a very strong science fair program (which... has sadly been dying over the past few years since they cut the middle school program), I actually met my first mentor when my mother got me a phone number of a professor at OSU from one of her co-workers. My mother has a B.S. in Accounting and my father has a Ph.D. in Applied Mathematics. This professor didn't want to take me at the time because I was a 7th grader, couldn't drive, and presumably had no clue what the hell I was doing. My 5 page review of literature written from searching "apoptosis" on the NCBI's PubMed website and the college textbook on Immunology she lent me convinced her that I could think. My first project was basically fed to me - but it was chosen because I expressed an interest, specifically, in T-cells. At the time, I couldn't even focus the microscope on the hemacytometer I was supposed to be using, much less count the cells in the grid. </p>
<p>My current mentor is a graduate student who still works in that lab who helped me focus said microscope in 7th grade. So yes, I've been working with her for nearly 6 years now, and even now, my projects are in large part the product of brainstorming from the both of us. We are on the cutting edge of virology, and what I do is largely affected by the resources that the lab can provide me, but over the years, my mentor and I have made sure that my project is a separate entity from hers. But as I've worked with my mentor in that lab and followed her research and the research of others in the field, I've become better able to direct my own path of research because I actually know what's going on, and I can articulate that very well. (You can't just ask for your own project. Professional researchers have a hard enough time figuring out what they want to do, without trying to come up with a project for you too.)</p>
<p>It takes most people a lot of time to be able to do serious research because of all the background one needs. I think I'm perfectly justified in saying that just about everyone who works in medical research once started out counting cells in a hemacytometer or using flow cytometry. No one likes to do it, but that's how everyone starts. I've done immunoflourescence and immunohistochemical staining myself lots of times, but only learned how to do a Western Blot and gel electrophoresis last year - and my first looked like the Loch Ness Monster.</p>
<p>But I have to say - while there are a lot of us who did our own research and have worked years to finally be able to understand and direct our own research, and we deserve to be lauded for it, I also have a lot of respect for those people who decided simply to do a project their junior or senior year and became semi-finalists. I personally know a semi-finalist who worked in engineering for 5 years and then decided to switch to biochem. While I don't think she actually submitted her biochem project, which she did at a University over the summer under the careful guidance of a couple proffesors, for ISTS, she did qualify to ISEF with it. This girl had absolutely no experience in biochem whatsoever prior to that summer. Yet she learned all the lab protocol and the background knowledge and the current research going on in order to be able to present her project that well.</p>
<p>Furthermore, the ISTS application is not just a science fair project. It also includes an stats application that makes applying to any college look easy, six detailed essays about your philosophy on scientific research, three teacher recommendations, one mentor letter describing how your research was actually yours in addition to the research paper. The ISTS doesn't necessarily look for the most amazing research project - it looks for students who have a passion and really want to pursue a career in research. That's why the prize is a scholarship.</p>
<p>So look at me compared to Ms. Ramakrishnan:
I got help from my mentor because I can't be unsupervised in the lab. While I knew what I wanted to test for I don't have the background to actually transiently transfect any of the cells I used (they were knockout cells, I did an add-back study of a protein I've been working with for 4 years). I'm not allowed by the SRC chair OR the University to actually infect the cells with the virus I studied (I watched my mentor do the infection), and I while I knew other lab procedures, I learned the Western Blot and gel electrophoresis as I was doing my project last year.</p>
<p>But the fact remains that I was there to do whatever parts of the experimentation I could do - that my first Western Blot looked like a Loch Ness Monster (yes, 6+ hours of benchwork in the lab come to nothing) - that I spent well over 150 hours on this project, that I had 5 years of experience in the field, and that I knew my project sufficiently well to articulate it in front of countless judges (no, I'm serious, I lost count) at my state fair and win 3 awards and 2 scholarships from it.</p>
<p>So many people don't understand that research is not something you do alone. That's why there are so many names appended to research papers. Simply put, not everyone can be an expert in everything. When I did projects in 9th and 10th grade involving immunohistochemical staining, it was not me nor my mentor who made the stains - it was another professor who worked in our lab: who we endearingly refer to as our "resident Stain-master." For my last project, both my mentor and I were learning virology at the same time (research takes you interesting places) with lots of help from the hall across the street because we actually work in a tumor immunology lab. And if nothing else, it was still that professor who afforded us the materials to conduct the research and gave us advice when we were stuck. It's truly a team effort. </p>
<p>So, quite frankly, it sounds to me that Ms. Ramakrishnan was simply being modest and giving credit where credit was due, just like I would in her place.</p>