I think some of the women’s colleges are more accepting. I agree with the post above about gaming/anime being hobby vs career. My aspie D (younger though in HS) really is into both of those hobbies but it is more of her escape from everything else. Her academic talents are different. I think fit for your niece is probably the first factor to consider. Another option if she is willing to travel is looking in the PNW at schools. Whitman, University of Puget Sound and perhaps U of Washington although its huge. There are companies out here that actively recruit and train people on the spectrum. Particularly Microsoft.