I am in a similar spot. You have a phenomenal trajectory, solid testing and respectable ECs. Truth be told, I’d put Michigan, BC and Northeastern closer to targets, maaybe low reaches. UPenn ED is a crapshoot for anybody, CMU is tough for anybody, Don’t know much about Case Western, NYU low reach, Cornell reach. Your sister attending BU won’t help if you go RD.
Overall, I think you’re underestimating yourself. Top 25% with a 33 on the ACT is very solid. I would look in to some SAT2’s to beef up your profile.