IF OP definitely has admission, and costs covered, at a state school in Miss, then IMO it’s OK to apply to academic reaches too.
It might be a waste of time if the financial situation with the restaurant as an asset precludes need-based aid, though. It might be a good idea to look also at schools that offer lots of merit aid, if the goal is to get out of state.
Or, take the free ride that is likely in Miss and plan to spend a year abroad, try to work summers outside the state…cure the wanderlust another way.
If you stay with premed, you will almost certainly apply to Miss Med school as it favors Miss residents and will be much cheaper if you do get in.