Colleges in the 2021-2022 Academic Year & Coronavirus (Part 2)

[ucbalumnus]

@vpa2019

Some of those vaccines have lower efficacy rates against original Covid and have they been studied/trialed against the variants?

Some have been observed relative to variants.

Fully vaccinated - How or Will Your COVID Routine Change?

The actual paper notes some nuances, particularly one versus two doses (the UK prioritized getting first doses out, so many people got one dose but spent a lot of time in that state waiting for the second dose): See table 2 on page 17-18. Two doses of Pfizer - BioNTech resulted in 100% antibody prevalence in ages 18-79, 97.8% in ages 80+. But one dose resulted in antibody prevalence that declined by age from 100% in ages 18-29 to 32.3% in ages 80+. For the Oxford - AstraZeneca vaccine, two doses resulted in antibody prevalence from 100% in ages 18-39 down to 83.6% in ages 80+, but one dose resulted in antibody prevalence from 72.2% in ages 18-29 to 46.3% in ages 80+. Vaccine 1d vs Alpha 2d vs Alpha 1d vs Delta 2d vs Delta Pfizer - BioNTech BNT162b2 49% 93% 33% 88% Oxford - AstraZeneca ChAdOx1 51% 66% 33% 60% (1d = 1 dose, 2d = 2 doses, Alpha = B.1.1.7, Delta = B.1.617.2)

There have been some studies by vaccine companies on neutralization of variants by original vaccines.

Inside Medicine. What Are You Seeing? [COVID-19 medical news]

Moderna describes vaccine-induced antibody neutralization response to several variants of COVID-19, based on sera from 8 vaccinated individuals. https://investors.modernatx.com/news-releases/news-release-details/moderna-provides-clinical-update-neutralizing-activity-its-covid Note that this is similar to what J&J - Janssen described (linked in post #3205). Summary of neutralization reduction (N-fold) compared to ancestral variant (higher number = greater reduction in neutralization = greater risk of vaccine being less effective): Variant Greek Letter Moderna J&J - Jannsen B.1.1.7 Alpha ~1 0.9 B.1.351 Beta 7.3-8.4 3.6 P.1 Gamma 3.2 3.4 B.1.617.2 Delta 2.1 1.6 B.1.525 Eta 4.2 B.1.617.1 Kappa 3.3-3.4 A.23.1 ~1 A.VOI.V2 8.0 B.1.617 1.5 P.2 2.2