I will let the LA driving pros give their advice but here’s a couple hotels if you are in their neighborhood. Nothing around USC except downtown hotels - too expensive then big parking fee on top of that. The Radisson across from USC is nice but always seems full.
I have students at USC, so I stay in Manhattan Beach (Marriott) when down there.
http://www.marriott.com/hotels/travel/laxmn-manhattan-beach-marriott/
The Embassy Suites that is located near Chapman is really newish and nice if you need to stay in that area, and suite style comfy.
Don’t stress the traffic, it is a fact of life there, just take in socal while sitting on the 10 and 405 and enjoy!!!