Help! Put wrong class size on Common App..

I was under the impression that the class size was 420 when it was actually 510. I got my class ranking correct but put the class size in wrong, and I already submitted to all my schools.

Is this a serious mistake? Should I call each school and let them know that I made the mistake, and will it affect my chances of admission if I don’t?

I can’t imagine that it will make much difference in your admissions odds. If you do want to contact the adcoms in charge of your region of the state/country, then do so.