Inside Medicine. What Are You Seeing? [COVID-19 medical news]

[Nrdsb4]

In fact, taking glutathione by mouth does not appear to be an effective way to get it into your body. It is thought that glutathione may be broken down by enzymes in the stomach.

Some other studies looking at its health effects have used it in injection form or as a treatment inhaled into the lungs.

https://www.webmd.com/vitamins-and-supplements/glutathione-uses-risks

[emilybee]

Putting this here for the science people to read.

https://baptisthealth.net/baptist-health-news/new-stem-cell-therapy-for-covid-19-finds-success-in-clinical-trial-at-baptist-health/

[dietz199]

Wonder how long before Amazon sells out of glutathione…

[evergreen5]

@dietz199

Wonder how long before Amazon sells out of glutathione…

My rough understanding is as noted in post 700, that non-oral forms (IV and nebulized) may be more usable than oral ones. For oral, there’s the precursor NAC (n acetylcysteine).

[BunsenBurner]

You can up your glutathione (GSH) levels naturally… by not drinking alcohol.

[Midwest67]

@BunsenBurner

Shut. up.

[dragonmom]

@BunsenBurner

You can up your glutathione (GSH) levels naturally… by not drinking alcohol.

Well, that might be an interesting study…I’d be on the wine end of it, but worth somebody’s MS in epidemiology.

[Nrdsb4]

@BunsenBurner

You can up your glutathione (GSH) levels naturally… by not drinking alcohol.

Uh oh…

[dietz199]

^^^ I’ll drink to that!

[garland]

Seconding “uh oh.”

[BunsenBurner]

We are all DOOMED.

[evergreen5]

But seriously, if we were to avoid things that deplete glutathione, acetaminophen would be very high on the list.

(random thought: what portion of severely ill COVID patients are taking tylenol - for fever, I suppose - in the hospital? what portion of older people take tylenol more generally, on a daily basis? I’m pretty sure my 80 y.o. mom does.)

[3kids2dogs]

I am trying to stay out of the COVID threads and don’t have the background for any of it and feel I am swayed media spin, but decided to ask this here because it seems like the people conversing in this thread really understand the science. This popped up on Yahoo Finance (more up my alley) yesterday. I recognize it’s just a compilation of data and not a structured experiment, but does it have any value? https://finance.yahoo.com/news/covid-19-mmr-vaccine-preprint-224605821.html

[Mwfan1921]

@3kids2dogs

I am trying to stay out of the COVID threads and don’t have the background for any of it and feel I am swayed media spin, but decided to ask this here because it seems like the people conversing in this thread really understand the science. This popped up on Yahoo Finance (more up my alley) yesterday. I recognize it’s just a compilation of data and not a structured experiment, but does it have any value? COVID-19 / MMR Vaccine Preprint Available: World Organization Has Completed Its Research

That seems promising…there has been some interest in current vaccines and their potential protection against sars-cov-2 infection.

Seems reasonable for people, especially older adults, to talk with their doctor about getting an MMR vaccine if they haven’t had one for awhile.

There looks to be only one registered clinical trial of MMR, with results due in the fall/winter. https://www.clinicaltrials.gov/ct2/show/NCT04357028?term=mmr&cond=sars-cov-2&draw=2&rank=1

[suzyQ7]

@Mwfan1921

@3kids2dogs

I am trying to stay out of the COVID threads and don’t have the background for any of it and feel I am swayed media spin, but decided to ask this here because it seems like the people conversing in this thread really understand the science. This popped up on Yahoo Finance (more up my alley) yesterday. I recognize it’s just a compilation of data and not a structured experiment, but does it have any value? COVID-19 / MMR Vaccine Preprint Available: World Organization Has Completed Its Research

That seems promising…there has been some interest in current vaccines and their potential protection against sars-cov-2 infection.

Seems reasonable for people, especially older adults, to talk with their doctor about getting an MMR vaccine if they haven’t had one for awhile.

There looks to be only one registered clinical trial of MMR, with results do in the fall/winter. https://www.clinicaltrials.gov/ct2/show/NCT04357028?term=mmr&cond=sars-cov-2&draw=2&rank=1

This is fascinating. I wonder of if the children of anti-vaxers have a higher incidence of Covid.

[Mwfan1921]

@suzyQ7

@Mwfan1921

@3kids2dogs

I am trying to stay out of the COVID threads and don’t have the background for any of it and feel I am swayed media spin, but decided to ask this here because it seems like the people conversing in this thread really understand the science. This popped up on Yahoo Finance (more up my alley) yesterday. I recognize it’s just a compilation of data and not a structured experiment, but does it have any value? COVID-19 / MMR Vaccine Preprint Available: World Organization Has Completed Its Research

That seems promising…there has been some interest in current vaccines and their potential protection against sars-cov-2 infection.

Seems reasonable for people, especially older adults, to talk with their doctor about getting an MMR vaccine if they haven’t had one for awhile.

There looks to be only one registered clinical trial of MMR, with results do in the fall/winter. https://www.clinicaltrials.gov/ct2/show/NCT04357028?term=mmr&cond=sars-cov-2&draw=2&rank=1

This is fascinating. I wonder of if the children of anti-vaxers have a higher incidence of Covid.

Isn’t that an interesting thought? Hmmmm

Not only are researchers looking at MMR, but also oral polio vaccine (OPV) and TB (BCG vaccine). There is a lot of opinion out there that BCG in particular protects infants from other respiratory diseases.

[evergreen5]

If you want to get into the immune system weeds: “T cells found in COVID-19 patients ‘bode well’ for long-term immunity”
https://www.sciencemag.org/news/2020/05/t-cells-found-covid-19-patients-bode-well-long-term-immunity#

two studies reveal that infected people harbor T cells that target the virus—and may help them recover. Both studies also found that some people never infected with SARS-CoV-2 have these cellular defenses, most likely because they were previously infected with other coronaviruses.
. . .
The more than 100 COVID-19 vaccines in development mainly focus on another immune response: antibodies. These proteins are made by B cells and ideally latch onto SARS-CoV-2 and prevent it from entering cells. T cells, in contrast, thwart infections in two different ways. Helper T cells spur B cells and other immune defenders into action, whereas killer T cells target and destroy infected cells. The severity of disease can depend on the strength of these T cell responses.
. . .
“These papers are really helpful because they start to define the T cell component of the immune response,” Rasmussen says. But she and other scientists caution that the results do not mean that people who have recovered from COVID-19 are protected from reinfection.

To spark production of antibodies, vaccines against the virus need to stimulate helper T cells, Crotty notes. “It is encouraging that we are seeing good helper T cell responses against SARS-CoV-2 in COVID-19 cases,” he says. The results have other significant implications for vaccine design, says molecular virologist Rachel Graham of the University of North Carolina, Chapel Hill. Most vaccines under development aim to elicit an immune response against spike, but both studies determined that T cells reacted to several viral proteins, suggesting that vaccines that sic the immune system on these proteins as well could be more effective. “It is important to not just concentrate on one protein,” Graham says.

The two studies that the above news article is discussing:
https://www.cell.com/cell/fulltext/S0092-8674(20)30610-3
https://www.medrxiv.org/content/10.1101/2020.04.17.20061440v1

Better understanding of the immune system is one nice angle to come out of covid research. (I have a kid with an immune issue who has had “experimental” non-FDA-approved Labcorp T cell testing done multiple times, so I’ve been trying to get a handle on understanding for years. It’s extraordinarily complex and much is unknown.)

[ucbalumnus]

@3kids2dogs

I recognize it’s just a compilation of data and not a structured experiment, but does it have any value? COVID-19 / MMR Vaccine Preprint Available: World Organization Has Completed Its Research

The actual paper theorizing that rubella vaccine is protective against COVID-19 is here: https://www.researchgate.net/publication/341354165_MMR_Vaccine_Appears_to_Confer_Strong_Protection_from_COVID-19_Few_Deaths_from_SARS-CoV-2_in_Highly_Vaccinated_Populations

However, wasn’t rubella endemic before rubella vaccine? What percentage of people old enough to have not gotten rubella vaccine got the actual wild rubella? Would getting the actual wild rubella have similar protective effects (if any) as the rubella (live virus) vaccine?

[TatinG]

The rubella-only vaccination was available and widely done in the 1960’s. Many children in the 60’s and before had measles and mumps. Is there something different in the MMR vaccine from ‘wild’ measles and mumps combined with a rubella vaccination?

[ucbalumnus]

@TatinG

The rubella-only vaccination was available and widely done in the 1960’s. Many children in the 60’s and before had measles and mumps. Is there something different in the MMR vaccine from ‘wild’ measles and mumps combined with a rubella vaccination?

https://www.cdc.gov/rubella/about/in-the-us.html says that rubella (“German measles”) vaccination started in 1969 in the US. Measles vaccine started in 1963 (but earlier ones were less effective), and mumps vaccine started in 1967. The MMR combination became available in 1971.