@Nrdsb4 @3SailAway @rjm2018 On the addition of zinc some of you were discussing earlier, I came across this from a few days ago, not sure if it was mentioned already:
https://www.ny1.com/nyc/all-boroughs/news/2020/05/12/nyu-study-looks-at-hydroxychloroquine-zinc-azithromycin-combo-on-decreasing-covid-19-deaths
How much risk is there from surface contamination?
There are a few medical papers around finding evidence of virus on surfaces and how long they remain, but not much in terms of the actual risk of infection from touching a surface that someone with the virus touched (e.g. door handles, shopping carts, touch screens or buttons on pay consoles or ATMs, etc.).
There is this page https://www.aba.com/news-research/references-guides/confronting-covid-analysis-surface-contamination-risks from a non-medical writer that suggests that only the more recently touched surfaces would be of significant risk, but is there anything from medical research on the subject?
Re mask efficacy data - my husband showed me a recently-published summary of old research (about 100 years old) showing that cloth masks did make a difference for HCW in preventing spread of TB and other infections. In fact, they were initially only using gauze and sometimes only one- or two-ply gauze. Several studies showed that for example, nurses wearing no mask got infected 23% of the time and wearing a gauze mask got infected 8% of the time. Not perfect, but definitely better than nothing.
Apparently, in the US, disposable masks came into larger use in the 1940s, but cloth masks were used, and were effective (certainly vs. bare face) before that.
Thanks @BunsenBurner!
Wow. Working with TMS cyanide on a production scale? Thatâs frightening. My hatâs off to those guys!
@scout59 - yup, nasty $&@#! Never done production runs⊠only smaller scale⊠transferring 2 liters of t-BuLi solution into a reaction mix was enough for me. I gave up the cannula and just slowly dumped it in under a healthy blanket of argon. ? I am a wimp. ?
Paging @doschicos!!! Have not heard from you in a while. Let us know if you are OK.
Regarding the news article I posted in #780 about the NYC study on the addition of zinc to the protocol, here is the paper, if anyone was looking for it: https://www.medrxiv.org/content/10.1101/2020.05.02.20080036v1
There are several new clinical trials of various types involving zinc supplementation. Apparently quercetin is also an ionophore and I see one trial involving quercetin but not with zinc.
Interesting protocol ideas from Eastern Virginia Medical School: https://www.evms.edu/media/evms_public/departments/internal_medicine/EVMS_Critical_Care_COVID-19_Protocol.pdf
How can you tell the kn95 are fake? My D has one given to her by a co-worker and wondering now if itâs fake.
@BunsenBurner - Iâm no big fan of t-butyl lithium either! (Especially after what happened to that UCLA student, Sheri Sangji)
The worst thing I ever worked with on a large scale (>100 grams) was phenacyl bromide - like the active ingredient in chemical mace, only worse. I thought I was being careful, but I wound up in the emergency room that night with the most painful blistering skin rash.
I have nothing but respect for process chemists and people who work in chemical/pharmacy manufacturing.
I googled this a few days ago and the first one that always shows up is that if they have ear loops, they are fake.
You can google and find a lot of hits on this.
Some of these are on sites not allowed to be linked on these forums.
However, the US CDC has a page on the subject:
https://www.cdc.gov/niosh/npptl/usernotices/counterfeitResp.html
Mixed vaccine news:
Sinovac (a Chinese company) reported good results in 8 monkeys.
https://www.sciencemag.org/news/2020/04/covid-19-vaccine-protects-monkeys-new-coronavirus-chinese-biotech-reports
The Oxford vaccine, not so good results. All monkeys were infected when challenged, but disease was moderated. https://www.forbes.com/sites/williamhaseltine/2020/05/16/did-the-oxford-covid-vaccine-work-in-monkeys-not-really/#70aab7e83c71
Leaders of UK and Italy stated their countries need to adapt to the virus, and donât count on a vaccine. Not sure if that was a reaction to the Oxford data, or what.
https://www.cnbc.com/2020/05/17/european-leaders-are-blunt-a-vaccine-wont-come-soon-enough.html
@evergreen5, thank you for the info. I canât remember where I read it but something re: the addition of azithromycin might be the instigating factor causing the prolonged QT intervals in some patients. I would like to see a study where the AZ is taken out, maybe a study comparing HCQ alone to HCQ and ZN.
Also, the part I bolded makes sense as the viral load is already too high once the patient reaches a critical stage and youâre no longer battling the virus but the inflammation, cytokine storm and organ damage that has occurred. Just like Tamiflu for the flu, itâs most effective given early.
*Edited to mention that the part I bolded is linked under the second âshow previous quotes.â
@evergreen5, their protocol is very detailed. I like the fact they acknowledge right from the get-go that the treatment is fluid based on latest research and sharing of info from what others are seeing and learning! So refreshing to see!
That protocol looks drug-heavy, with not a lot of evidence to support it.
https://covid19criticalcare.com/
@evergreen5, looks like one of the main EVMS doctors from the link you shared is using the MATH+ Protocol in addition to other drug treatments.
Several pulmonologists/intensivists from around the country are using this protocol and sharing their thoughts in the video in the link I provided above. Fascinating to see such collaboration and fast tracking of treatments that are showing promise!
** Methylprednisone, ** Ascorbic Acid (IV), ** + ** ** Thiamine, Zinc, Vit D and LMW ** Heparin.
Iâm not sure your point? Are you suggesting this protocol doesnât make sense, or should not be used?
Theyâre probably using a decision tree for some of the drugs listed on the EVMS protocol that @evergreen5 linked based on EKG, Echo, CXR, CAT Scan, etc. and levels of D-dimer, Ferritin, CPK, Lymphocytes, LDH, CRP. Troponin, CBC, CMP, PT/PTT, etc.
Iâm saying theyâre using a lot of drugs for which the evidence is scant. Some of those drugs are the usual suspects that are suggested for everything: zinc, Vitamin C, Vitamin D, melatonin. Hydroxychloroquine? Thereâs evidence about that one, and the evidence is against it.
Talked to a Nurse at Emory tonight . She says the most promising is the plasma from recovered patients. She also said that they are getting less and less showing up at the hospital, but still are having to Vent people.