Inside Medicine. What Are You Seeing? [COVID-19 medical news]

The odds are a little higher that your H is A- if one of your offspring is -. He’s AO in order for one to be O (it’s recessive). “-” is recessive too, so there’s a 25% chance of a “-” offspring if you both are heterozygous +/- and 50% if he’s “-.”

What is the false negative rate of tests for current infection of COVID-19?

Thank you so much for posting this!

A+ here, as are both Ss. I used to say that’s why I’m so smart. Lol. I also can’t donate because of low hemoglobin. It’s high enough that I’m not anemic, but just below the threshold to donate. I tried 3x and turned away twice. The third time I made the min level on the nose. Donated and wound up anemic for 6 weeks. Boo.

In my early adult life (pre children) I never weighted enough to donate. When I fit the weight, I had had chemo, so was not able to donate. My BIL donates regularly and was quite upset during COVID when he couldn’t donate. He usually goes to his synagogue during a drive, but this time he would have to go to the Red Cross and was not comfortable with the processes in place as he is 67.

DH just gave (he is B+) at red cross, but routinely helps out/donates at the synagogue drive that is the oldest ongoing blood drive in the city.

At red cross they asked if he was interested in giving plasma, but he has stopped that b/c they now take out of both arms at the same time and he cant stand not being able to use either hand for like an hour and a half! (I think thats how long he said it took). So they didn’t give him an antibody test.

A+ here, too. And the Red Cross asked me not to come back to donate anymore because I’m such a tough stick. :frowning:

I bet there is a correlation that people with A+ blood remember their blood type more than people with other blood types. For me, being told i am A+ had a pleasing ring to it. But, to get back to my earlier post, I was somewhat kidding about disappointing myself. I am concerned though about what i read in the NYT that having Type A blood was linked to a 50 percent increase in the likelihood that a patient would need to get oxygen or to go on a ventilator. https://www.nytimes.com/2020/06/03/health/coronavirus-blood-type-genetics.html

@silverpurple, yes, ha, I like being A+ since I made good grades in school. And my husband is B+, which fits his personality. :slight_smile:

D and I both donated blood last week. Our local blood donation organization is doing antibody testing on all donors - we were both negative. They are using the Ortho-Clinical Diagnostics Total test, which seems to be very accurate.

https://www.fda.gov/medical-devices/emergency-situations-medical-devices/eua-authorized-serology-test-performance
We’re both O+, so I guess that’s a good thing.

@MaineLonghorn I am the opposite. Nurses love my veins. From all my lifting and running, I’ve got veins popping everywhere. One of our friends is a nursing instructor and she mentioned she’d love to have me come in and have her students practice on me.

I would donate regularly if I could. Needles and blood don’t bother me. I would try if my kids or family needed it. But 6 weeks of anemia just wasn’t fun.

Did someone mention this already? A randomized trial out of Minnesota (and published in the New England Journal of Medicine) found that hydroxychloroquine has no benefit over placebo in preventing COVID-19 among those exposed to the virus.

https://www.nejm.org/doi/full/10.1056/NEJMoa2016638?query%3Dfeatured_home=

I was running 30 miles a week and going to CrossFit regularly, but it didn’t make a difference. :frowning:

https://www.cnbc.com/2020/06/08/asymptomatic-coronavirus-patients-arent-spreading-new-infections-who-says.html

This is interesting - and good news. Maybe then all those temp checks being proposed ARE a good idea. I was under the impression that this spread mostly or equally by asymptomatic people… WHO says its not so.

There could be a difference between asymptomatic people (who will never develop symptoms) and presymtomatic people (who will develop symptoms later). Other research suggests that infected people (at least those who develop symptoms) are most contagious a few days before they develop symptoms. Some of the superspreading events had the superspreader who was, at the time, well enough to eat in a restaurant, go to work, sing in a choir, etc…

But then, if contagiousness (rather than infection) is the target for testing, the best kind of test would be a rapid inexpensive breath based test to detect SARS-Cov-2 in one’s exhaled breath (the primary means of spreading). It would have to be rapid and inexpensive so that it can be done every day (e.g. to test employees in higher risk of spreading jobs, or students going to class in high school or college).

The same WHO doctor who said asymptomatic spread was “very rare” also talked about how some people who are called asymptomatic actually have mild symptoms. I couldn’t tell whether she meant to say that the people with the mild, never-recognized-as-covid symptoms also “very rarely” spread the disease. She might have meant that truly asymptomatic people don’t spread it, but people with mild disease do spread it.

WHO should do better about clear communications.

I posted this in the other coronavirus thread, but then realized it was probably better to ask here:

Here’s one result on obesity, from Britain: If an obese person (of unknown age) was admitted to the hospital for covid, they had a 1.3 times bigger chance of dying than all patients who were admitted to the hospital and were under 50. That is, if someone was admitted to the hospital for covid, and the only thing we knew about them was that they were under 50, they had some risk of dying, and if the only thing we knew about them was they were obese, they had 1.3 times that risk.

If the only thing we knew about the person was they were in their fifties, they would have a 2.63 times bigger chance of dying. In their sixties? Five times bigger. And obviously it would be much worse for older people.

So, given that you’ve been hospitalized for covid, your odds of death are not much worse if you’re obese. But this doesn’t account for whether obese people are more likely to be hospitalized in the first place. They are, as we see from the next paper.

https://www.bmj.com/content/369/bmj.m1985

Here’s one from New York, about people who showed up with covid-like symptoms at the ER at NYU Langone, and who tested positive for covid. Mildly obese people (BMI 25-30) were slightly more likely to be admitted than nonobese people (OR 1.3). Obese people (BMI 30-40) were more likely to be admitted (OR 1.8). Very obese people (BMI 40+) were much more likely to be admitted (OR 2.45).

A selection bias might well be seen here as well. Nonobese people might not get sick enough to show up at the emergency room; this paper doesn’t tell us.

https://www.bmj.com/content/369/bmj.m1966

Agree. Very poor communication. Today they are trying to clean it up:

https://www.cnbc.com/2020/06/09/who-scrambles-to-clarify-comments-on-asymptomatic-coronavirus-spread-much-is-still-unknown.html

An asymptomatic person is someone who doesn’t have symptoms and never develops symptoms. It’s not the same as someone who later develops symptoms, who would be classified as pre-symptomatic, WHO officials said.

Though we are still waiting for the 18 clinical trials involving ivermectin, some results finally out of Broward County, Florida:

https://www.medrxiv.org/content/10.1101/2020.06.06.20124461v1