I am sympathetic with your desire to leave your home state, go out and see the world, and challenge yourself. It is admirable to be so bold. However, the OOS schools you list are tough to get into and expensive. It is entirely possible none of them will be an option, so you have to wrap your mind around the chance you will be in SC.
I know it won’t be easy, but try to see the pluses of staying in state and accept that as an option. Not a done deal, but an option.
Big state schools have lots of money in the sciences. You will find some good profs and some good labs. They may be tougher to find, and you may have to ferret them out yourself, but they exist. State flagships have a gamut of course offerings, and their programs are accredited. Moneywise, there are likely incentives to keep strong students in state. You will have less debt, which you don’t appreciate so much now, but will when you get out and want to buy a car or house. Big state schools are diverse. There are all kinds of clubs and sports and people. Big state schools have large, enthusiastic alumni networks. Somebody from SC works at NASA and would love to talk to you.
I have a kid at a LAC and one at a State Flagship. There are advantages and disadvantages to both. My LAC kid looks wistfully at his bro and does wonder what his life would be like if he had gone there. Whatever way it works out for you, my advice would be to be all in. If you get out of SC, good for you; embrace it. If you don’t, same thing.