I went to Middlebury, and now have two kids at somewhat isolated schools - one at a southern LAC (Hendrix) and one at Virginia Tech. I was apprehensive about Midd because of its its isolation, but its rural character is now the part I miss about it the most. Even dealing with snowstorms over Thanskgiving led to some great memories. Unless you are someone that just can’t survive without the buzz of a city, don’t worry about where your college is - just go for the best fit and it will work out. However, I would say that a car is a huge benefit if you are going to be out in nowheresville.