PLTW or AP classes?

my high school has this really good system called PLTW Biomedical program from mid sophomore to senior year and you can do it with the IB diploma program. It helps you get experience for the medical world and uses many tools that hospitals and labs use. It is a really good program to get you familiar with a daily life experience for doctors. It is a pretty well known system for preparing students for the future.
The problem is, it replaces your Science classes. Its gonna replace my AP chemistry, AP bio, and physics honors class. Will it impact me in a negative way? Will I have a disadvantages to other students applying to prestigious colleges?

No. Every single AO is familiar with the rigor involved with PLTW. Good luck.