I think it depends on the OP’s objective. If the goal is medical school , any of the schools will be fine. If the goal is academic medicine and research (the MD/PhD track) Michigan offers more research opportunities than Georgetown or ND. Michigan also admits many of its own undergrads to medical school. Michigan has the enormous (former Pfizer research labs) NCRC complex, which cost Pfizer over $1 billion to build, the majority of which is dedicated to medical research in addition to all of the labs and research facilities already on campus.
Pre-med could be just about anything these days , and pre-med students sometimes change their mind and go into other fields. Michigan and ND have very strong alumni networks so that may also be a factor. Both ND and Michigan are strong in many areas, and the OP might make a shift from, say, the science to business. Unless the OP is 100% certain of their path that should also be a consideration. 18 year old students can change their mind frequently.