<p>My friend and I or My friend and me</p>
<p>how do you determine those?</p>
<p>both of those are for different uses in the sentence.</p>
<p>My friend and I were beaten up by the bully.
The bully beat up my friend and me.</p>
<p>At beginning of sentence, My friend and I.</p>
<p>And it depends on context too.</p>
<p>Easy. Take out "my friend" and read the sentence without it. That should tell your ear immediately whether "I" or "me" is correct.</p>
<p>Example:
My friend and me went to the store.
Me went to the store.</p>
<p>You know the second is wrong, so the correct response must be "My friend and I".</p>
<p>(Oh, one more thing: it is always "between you and me." No matter how many times people say "between you and I", that is always wrong.)</p>