<p>^Hahaha yeah 83a was kinda like a *** moment, while 84 made sense after I looked at the answer, but I don’t think I would have thought about that on the midterm. Damn reagents from first part!</p>
<p>how do you make that second enolate though? there’s no base</p>
<p>When you reform the first enolate it kicks off the double bond to grab the H+ (from the H+/H2O) so you are left with water which becomes the base to grab an alpha hydrogen to make the SECOND enolate.</p>
<p>thanx cb :)</p>
<p>im gonna effing fail. I only knew how to do like… 5% of the problems on the problem sets…</p>
<p>i’ve studied extremely hard for this one, i don’t remember the last time i’ve studied this much for an exam lol, i hope i do well =/</p>
<p>Yeah same here, but I did them a second time and went from getting like 5% the first time to getting almost all of them right the second time. I doubt I remember every problem, but IDK the second time I feel like you are so used to the problems that you don’t make the same mistakes that you did the first time. The first time I actually did some SN2 thingy, which was way wrong, but now I know to always use neighboring oxygens to kick off other charged oxygens to make alcohols. Don’t worry you will do fine!</p>
<p>Mech: Bio 1AL…to this day every time I see a rat I want to kill it because I slaved days to remember every ****ING pathway in its body.</p>
<p>rofl, i studied a lot for that one too, but that was just memorization so it wasn’t THAT bad, orgo is actually hard :(</p>
<p>don’t worry same boat. i don’t understand half of the synthesis questions thus far. haven’t even gone through all problem sets</p>
<p>do primary/secondary amines prefer to undergo 1,2 or 1,4 attack on alpha beta unsaturated carbonyls?</p>
<p>1,4 addition</p>
<p>i think you’re gonna do well calbear lol</p>
<p>hey calbear, if it goes through 1,4 addition why does a hydrazine attack it the carbonyl at the 1,2 in 188b? is it cuz that’s the only way (even though unfavorable) to get to the final product?</p>
<p>edit: jeez, 188b is insane</p>
<p>Yeah amines (NH2-R) usually go for the 1,2 to make water which acts as a leaving group to make the nitrogen double bond. Ugh I just realized he told us that amines go for 1,2 to make water which acts as the leaving group, but also said that almost everything besides Li-R adds 1,4. Damn you Pedersen.</p>
<p>aw that must be how you know, i see</p>
<p>stupid question but how do you count 1,2 and 1,4 addition? lol I can’t seem to wrap my head around it</p>
<p>make the oxygen 4 so the double bond is 1,2 and the carbonyl carbon is 3</p>
<p>Hey for identifying sugar linkages do you circle both the oxygen and anomeric carbon(1) or the oxygen, anemeric carbon and other carbon (3-4-6)? He seems to be kind of inconsistent in what he circles over different problems.</p>
<p>don’t think it matters lol</p>