The college you end attending: Is this actually determined in middle school?

Not taking calculus (or taking a watered down version) in 12th grade after completing precalculus in 11th grade can look worse than not taking calculus in high school because your middle school math placement led to precalculus in 12th grade. The former reflects a conscious recent choice to take a less rigorous option, while the latter reflects a placement decision made in middle school years ago for reasons that may no longer be relevant.