The importance of senior midterm grades and one bad grade?

I’m currently at my high school, and a senior applying to top schools, such as Emory, USC, Notre Dame, Brandeis, URocehster, Case Western Reserve University, Boston University.
I am taking AP Calculus BC and currently have a C+. Although I am trying to raise it to a B-, I want to know if the chances of me getting into these schools will be affected if I have As in all my other classes, including three other APs. I know the applicant pool is tough, but will one grade my senior year in the most rigorous available math class really hurt my chances of admissions to these school?
Also I have a 770 on SAT 1 math so its not like I am bad at math, its just that the class is very hard.

bump!

Hard to say. I know numerically there probably isn’t much difference between a C+ and a B-, but on the margin a B- will look better. I do know a student who was admitted to one of those schools last year after receiving a B- in an AP math class first semester senior year.

any other opinions?