Both schools are going to have a good number of 3.8+ GPA 35+ MCAT students. You do not have to be above average in your class to get into medical school. As long as your GPA and MCAT are in range for your target medical schools, it does not matter if you’re average in your class, you will have a good chance at medical school. UG does not really matter for med school, unless you want to go into academic/research medicine at schools like Harvard/Yale/Hopkins. Even if that was the case, a 3.9 GPA/40 MCAT student at UPenn isn’t going to look better than a 3.9 GPA/40 MCAT student at Georgetown based on college name/prestige alone. Major does matter a bit in terms of GPA. Having a below average GPA in a major like Engineering won’t look as bad, since it is considered one of the most rigorous majors at most schools. So to answer your question, no not really. Standing out is going to be exceptionally difficult at either school. I might give a slight edge to UPenn, though. Major doesn’t matter too much for Medical school, it really matters more in the context of GPA.