Worth it for an American to apply to European Universities? Which ones?

OP, I honestly do not mean to be snarky. But you are telling me you looked at the admissions websites for Oxford and Cambridge, and are still asking the Internet whether SAT 2s can be considered in lieu of APs? It says so right on those pages - Oxford will and Cambridge won’t, IIRC correctly.

Read the admissions information for international applicants, for both Oxford and Cambridge. Read them right through. They are very transparent. You will find out that you will need general entrance qualifications to even be considered at all, and special qualifications to be considered for a specific subject. History APs will be considered for subjects like history or PPE. Find the course that most closely aligns with your interest and read up on the specific requirements (I don’t think there is a course called international affairs at Oxford, don’t know about Cambridge). Again, those are cutoffs, not elements of holistic consideration.

You will then find out that of the candidates who apply having cleared those cutoffs, a number will be shortlisted for an interview. Around 30 to 50%, depending on the subject. And of those interviewing, a number will be admitted. Total admission rates fluctuate wildly depending on subject, may be anywhere from 10 to 30%.

If you are unwilling or unable to find all these things out by yourself, you are not a fit for Oxford or Cambridge and not a good fit for other UK unis, either, because your style of learning won’t work.