It sounds like people are eager to get vaccinated. 
@suzyQ7 I donāt think they are mRNA. Some other technique and they need only one shot that simplifies the process enormously. Not sure about refrigeration. It probably doesnāt require an extreme temperature like the Pfizer if it needs it.
The AstraZeneca vaccine does not use mRNA. It infects you with a modified chimpanzee adenovirus, modified to not make you sick and to make you develop immunity against covid. It needs to be stored in a normally-frozen freezer.
It will be interesting to see the efficacy of this type of vaccine vs the MRna. Hopefully soon.
AZ data isnāt due until around Christmasā¦remember AZD1222 was put on a 7 week hold in the US due to two neurological events in two patients. The first event was in July when a patient developed MS which was determined to not be vaccine related. The second event was a patient who developed transverse myelitis in September, that has not yet been determined to be vaccine related or not. https://www.clinicaltrialsarena.com/comment/azd1222-covid-vaccine-trials-astrazeneca/
The product requires two injections, but only has to be refrigerated (not frozen)ā¦and can be kept in the refrigerator for up to one year. https://www.statnews.com/2020/07/20/study-provides-first-glimpse-of-efficacy-of-oxford-astrazeneca-covid-19-vaccine/ and https://www.firstwordpharma.com/node/1741945
AZ/The Lancet published data in late October from a phase II study that show good immunogenic response. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)32466-1/fulltext
The two mRNA vaccines having such high levels of efficacy are going to put a lot of pressure on the following vaccines, yet the world needs more than two vaccines. Will the FDA approve a vaccine that āwould prevent disease or decrease its severity in at least 50% of people who are vaccinatedā(the previously communicated hurdle)? If not, what is the new hurdle? Will the FDA accept less risk from the later vaccines, e.g., transverse myelitis, or other side effects? No one knows the answers, but interesting to ponder.
Derek Lowe is a great resource to follow, google his name and āIn the Pipelineā to read his blog at Science Magazine dot org.
Here is a good graphical summary of where we are at with vaccine development, which also discusses how the window for recruiting vaccine studies may be closing: https://www.biocentury.com/article/632064
Our Walgreenās has had a āno Covid vaccineā sign for awhile - from before one had been determined to be effective.
Bumping this up (I hope).
Is it true that most antigen tests give false negatives? Or false positives? (I thought it generally was a 30% false negative rate.)
https://www.health.harvard.edu/blog/which-test-is-best-for-covid-19-2020081020734 indicates that the false negative rate for all kinds of tests is high.
One of the few threads I still visitā¦butā¦
Since I can not for the life of me figure out how to get to the last posting on a thread in a normal fashionā¦Iām making this post.
Thereā¦now I can go to my own history, click on this post and at least get somewhere near to where I want to be in a thread.
Appreciate the info presented hereā¦just not sure it is going to be worth the ongoing effort given the BTUās needed to make this new and improved stuff work.
Thanks for that info!
Last post is brought up by clicking on the time of last post. Far right side, when viewing threads.
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No one wants to be āthat family.ā These folks drew the worst straw possible. According to the article school was not in session, so transmission there isnāt to blame. It also says āCovid related illness.ā I wonder if thatās the syndrome showing up in some kids, something underlying, or something else. If anyone finds out anything more, please post.
Regardless, my heart goes out to them. Itās not the way one wants to beat the odds.
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very sad indeed
@Creekland - the press release from the hospital (quoted in the text of the article) said
āCOVID-19 related causesā so I am thinking that is Covid on top of some underlying condition.
We donāt know in this particular case, of course, but the most commonly reported conditions leading to pediatric death from Covid (deaths in patients under age 21) reported in one study āwere chronic lung disease, including asthma (34 [28%]), obesity (33 [27%]), neurologic and developmental conditions (26 [22%]), and cardiovascular conditions (22 [18%]).ā From https://www.cdc.gov/mmwr/volumes/69/wr/mm6937e4.htm
@calmom Yes, thatās what Iām referring to/asking about. If you see more posted than what was in the article, Iām curious from a medical perspective.
Canāt click through links on this thread. Is this a migration issue?
Yes, there seems to be a rendering bug where some features (including links, boldface, and italic) do not render āfor realā, even though they may render properly in the preview when you are composing or editing the post.
Yes, sad. My kidās high school! It pulls from a large area, but in many of the neighborhoods not far from the school, people are masking and distancing carefully.