I really like the K-State idea! For a student who loves bio/biochem but doesn’t want to work in health care (which is very much not for everyone, as many realize too late!), there are a lot of really fascinating opportunities in agriculture and related fields, many of which are at all not on the radar of kids who haven’t grown up in agricultural communities. A strong bio background is needed for many careers in horticulture, soil science, food science/safety, and so on. And it’s much easier for students to get connected to these fields at a college with an ag school, even if they don’t aspire to a farming-related career per se. The K-State website is a good place to browse majors and the kinds of research, graduate study, and careers that they can lead to. And the school itself is, while not LAC-sized, still a manageably-sized and supportive place to study - I’ve never heard a bad thing about it here on CC. She could very well qualify for the University Honors Program there, which would give her priority registration, Honors-specific classes (and the opportunity to upgrade non-honors classes to honors via contract agreements), and housing at the Honors House (which would provide a smaller, sub-community with high academic standards). I think it makes a great point of comparison with the small LAC’s, which could also provide a great experience for her but with arguably a narrower range of potential applications for what she’s learning.
If the idea of a manageably-sized public U with an ag school appeals, she might also look at UVM and UDel. The honors programs at these may be out of reach, but the schools themselves should be matches, I think. (Of course, UIUC has a great ag school too, with a somewhat less reachy stat profile than Arts & Sciences, and an Undeclared option that’s designed to allow students to explore the many interesting major options, including plant biotechnology, food science, agronomy and many more. It’s a large university, but there are only about 2700 undergrads in ACES. If your daughter has already ruled out applying to UIUC A&S, it might be worth tossing an undeclared app at ACES to keep the option open.)
You’ve got lots of good LAC options there also. Many of them are “Colleges That Change Lives” schools, so check out that website if you haven’t already ( ctcl.org ), both for the profiles of the schools you’re already considering, and to perhaps notice others that might be of interest.
Seconding Connecticut College as a reach that’s known for strong botany - potentially a good replacement for Wesleyan on your reach list. (Conn College actually exists because of the failure of Wesleyan’s first attempt to go coed.)
As a less reachy alternative to Wake Forest, maybe consider Sewanee? They have majors in Forestry and Natural Resources in addition to bio and biochem, in a gorgeous (albeit a bit remote) setting with a Greek system that’s known for being inclusive and supportive (perhaps more so than Wake’s).
In a completely different vein, if she really wanted to double down on Spanish and studying abroad, she could consider St. Louis U, which has a campus in Madrid. In addition to the traditional semester-abroad option, students can elect a 2+2 program where the entire first two years are spent in Spain.