AP Stat or AP Computer Science?

Equally interested in both for senior year, would like to know which looks better on an application. Will also be taking multivariable calculus, but I really like math.

Take the one that will help you most with your intended major(s). Also, there are two AP CS classes - APCSA (useful) and APCSP (mostly useless).

CS principles is probably more useful for a prospective non-CS major, or a student unsure of whether s/he is interested in doing a CS major. CS A is more applicable for prospective CS majors.

AP CS Principles will expose you to all the branches of CS. It’s a very useful class to help you think of possible majors and applications, and/or if you don’t have much experience programming.
AP CS A is for students who know they want to major in CS and (preferably) have some experience with programming. It’s not necessary, in that the best programmers practice on their own, but it can provide a good framework for that.
AP Stats is an elective; if you’re taking MVC, you would probably be taking it as a fun elective, like you would take digital design or theater tech. Make sure you take Statistics in college, regardless of major, because stats are always part of “relevant coursework” for a resume.