Inside Medicine. What Are You Seeing? [COVID-19 medical news]

It is sodium nitrite and citric acid. I can only imagine what sorts of profit margins they have. :slight_smile: At least there are no ingredients of questionable health risks.

ETA: nitrite, not nitrate. Ugh autocorrect. Nitrites are not completely harmless but at least the application is topical, and we all consume a certain amount of them daily.

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Shipped via DHL
starting point
Tel Aviv

Nope! and Nope.

Flu is caused by the inFLUenza virus. There are hundreds of viruses that cause the “cold,” and a few of them are coronaviruses.

ETA: Oops, should have read the rest of the thread before answering. Didn’t mean to dogpile.

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More affordable than Amazon!

Interesting study from NIH about long Covid amongst mostly non-hospitalized patients. Almost no sign of inflammation, organ damage etc but the main things it correlates with is being female and having a history of anxiety.

The paper is here: https://www.acpjournals.org/doi/10.7326/M21-4905

And a Twitter thread discussing it:
https://twitter.com/awgaffney/status/1528876982754476032

It seems like having diabetes also correlates. More so than anxiety disorders.

Women have rather interesting (and more complicated than men’s) immune systems, due to the possibility of pregnancy, which to the female host is like a malignancy (at least in the initial stages of pregnancy). I don’t know if I’m remembering this properly, but during pregnancy the woman’s immune system has to quiet down so as to not attack the embryo but has to also ramp up as to not contract any horrible illness. I’m not a medical doctor, can you tell :nerd_face:.

I’m a little disappointed by this study because it will allow doctors to continue to attribute a lot of women’s problems to anxiety. One of my friends struggled a lot with a post viral syndrome and was told over a period of years that it was anxiety. She persisted and is now being treated by a doctor that “believed” her. She is improving. I guess you could argue that she would have improved regardless
 Medicine is an art as much as a science.

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There are also immune system effects from different numbers of X chromosomes: The X chromosome and sex-specific effects in infectious disease susceptibility | Human Genomics | Full Text

Yes. I remember reading about this too. It’s so fascinating!

This article and study will be misconstrued and misused. It mentions chronic fatigue, fibromyalgia and would include Lyme disease as one of the post-bacterial conditions. It does day that an occult virus could remain in the body and not show up in testing. What other tests are possible that were not done? (Spinal tap, PET scan, I have no idea
)

To me, and I am a lay person obviously, there are two problems here.

One, the “anxiety disorder” is CURRENT at the time of the study. Wouldn’t people with long COVID have some anxiety about their challenges? Am I reading this incorrectly?

Two, recruitment differed between the COVID and control groups. The former was more passive so it is possible that a more anxious group might choose to sign up. There is possible bias in results as a result of differences in recruitment methods, in other words. (see below)

Nowhere does the study say that long COVID is a psychiatric disorder. It says that more study is needed. But the wording of the summary would seem to say sufferers have an anxiety disorder causing symptoms. Since when does anxiety affect the sense of smell?!

For the COVID-19 group, there was no active study recruitment process other than posting details of the study on ClinicalTrials.gov and the NIH Clinical Center websites. Participants in the COVID-19 group were enrolled regardless of the presence of PASC. Adults with no history of COVID-19 were recruited as a control group via the aforementioned websites and the NIH Office of Patient Recruitment Listserv, an e-mail list maintained for persons interested in receiving information about participation in studies being conducted at the NIH Clinical Center.

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From STAT

Long Covid numbers are growing, CDC says

(CDC)

More than one-third of adults recovering from Covid-19 still had problems one month to a year after they were infected, a new CDC report says about the rising number of long Covid cases. Among that 38%, older people fared worse: While 1 in 5 Covid survivors under 65 had persistent symptoms, 1 in 4 over 65 still suffered from lingering conditions, including more neurological problems. Covid survivors had twice the rate of pulmonary embolism or respiratory issues compared to similar people without Covid, while other long Covid symptoms spanned cardiovascular, pulmonary, hematologic, renal, endocrine, gastrointestinal, musculoskeletal, neurologic, and psychiatric conditions. The study, based on electronic health records from January 2020 through November 2021, did not take Covid vaccination into account. “As the cumulative number of persons ever having been infected with SARS-CoV-2 increases, the number of survivors suffering post-Covid conditions is also likely to increase,” the authors write, calling for routine assessment for post-Covid conditions.

Probably many would want to know how vaccination and/or prior infection affects the risk of long COVID in any new infection.

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I just tested positive for Covid. I think I got it at a graduation party. It was 50+ people at a small restaurant. I kind of expected it. It has been 3 days.
My doctor is prescribing Pexlovid for me. I am wondering if I should take it because I don’t feel horrible right now.

Take it! This disease can seem mild and then strike you hard. If it were me, I would take it immediately.

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Take it. I would.

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It’s through a NY program where a pharmacy will deliver it to my door.
My mother recovered on her own. There are some side effects associated with this medication. I am wondering if anyone has taken it here.

What really irks me when I asked my doctor (new to me) about whether I should take it. He wouldn’t recommend one way or another. He just told me about some effects.

Has the following:

  • “The drug, developed by Pfizer, has a lot of positives: It had an 89% reduction in the risk of hospitalization and death in the clinical trial that supported the EUA”
  • “You have to take Paxlovid within five days of developing symptoms. Like all antivirals, Paxlovid works best early in the course of an illness—in this case, within the first five days of symptom onset, says Jeffrey Topal, MD, a Yale Medicine infectious diseases specialist who is involved in determining COVID-19 treatment protocols for Yale New Haven Hospital patients.”
  • "Common side effects, which are usually mild, include:
    • Altered or impaired sense of taste
    • Diarrhea
    • Increased blood pressure
    • Muscle aches
    • Since Paxlovid is cleared by the kidneys, dose adjustments may be required for patients with mild-to-moderate kidney disease, explains Dr. Topal."
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I don’t think Paxlovid is all upside. I’d also google Paxlovid mouth. I’d personally rather have bebtelovimab monoclonal antibodies, if accessible.

Weren’t these statistics of efficacy for unvaccinated people? Maybe there has been a fully vaccinated and boosted arm added to the study? Not sure.

Unvaccinated, high risk and Delta variant:

“The population Pfizer studied in its clinical trial looked very different from the patients Paxlovid is generally being prescribed to. The former were unvaccinated, met specific high-risk criteria, and were infected with the Delta variant. The latter are generally vaccinated, fit a looser criteria for high-risk, and are infected with Omicron.”

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