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Interesting that I couldn't think of any schools in the midwest/south that feature prominently in pop culture, or even the big-time sports schools like Michigan, Duke, Notre Dame, UNC, Florida.
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<p>Northwestern is a Midwestern school that probably makes it into the top 10.</p>
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Fictional alumni of Northwestern include: Josie Geller (Drew Barrymore; Never Been Kissed), Andrea Sachs (Anne Hathaway; The Devil Wears Prada), Natalie Hurley (Sabrina Lloyd; Sports Night), Augie March (The Adventures of Augie March), Sara Tancredi (Sarah Wayne Callies; Prison Break), Liz Lemon and Jenna Maroney (Tina Fey and Jane Krakowski; 30 Rock), Danny Tripp (Bradley Whitford; Studio 60 on the Sunset Strip), Cheryl (Melanie Nicholls-King; The Wire), Teri Joseph (Nicole Ari Parker; Soul Food), Gomez (The Time Traveler's Wife), Lee (Jonny Lee Miller; Melinda and Melinda), Harry's wife (When Harry Met Sally), PJ Franklin and Brendan Dorff; (My Boys) and Dr. Temperance "Bones" Brennan (Emily Deschanel; Bones).</p>
<p> Fictional Northwestern students include Aaron Samuels (Jonathan Bennett; Mean Girls), Catherine Llewellyn (Gwyneth Paltrow in the film adaptation; Proof), Hannah (Jennifer Garner; Felicity), Jim Levenstein (Jason Biggs; American Pie 2), David (Jason Bateman; The Hogan Family), Joanie Cunningham (Erin Moran; Joanie Loves Chachi).</p>
<p> Fictional Northwestern faculty include Mrs. Heron (Ana Gasteyer; Mean Girls) and Dr. Adani (Shohreh Aghdashloo; The Exorcism of Emily Rose). </p>
<p> Fictional applicants to Northwestern include: Buffy Summers (Sarah Michelle Gellar; Buffy The Vampire Slayer), Liz Parker (Shiri Appleby; Roswell), Carmen (Masiela Lusha; George Lopez), and Moesha (Brandy Norwood, Moesha).
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<p>Northwestern was featured prominently in the Tom Hanks film Nothing in Common and Steve Martins character in The Cheaper by the Dozen films is the FB coach for a school thinly disguised as NU (NU refused permission to use its name).</p>
<p>NU is also has been mention in The Sopranos, Friends, Van Wilder. Beverly Hills 90210, License to Wed, The Breakup and numerous other films and TV shows.</p>