Chicago has a Chinese restaurant menu core with some side requirements, and some integration with stuff you might be taking anyway.
There are four special main areas that do not correspond to specific academic departments: Humanities (HUM), Arts (music, visual art, theater), Social Sciences (SOSC), and Civilization (CIV). You have to take one three-quarter seuence in SOSC plus six courses from HUM, Arts, and CIV, including at least two sequential courses in HUM and CIV, and at least one Arts course (so you can do 2-2-2, 3-1-2, or 2-1-3). The HUM courses must be taken first year, and include a first-year writing component.
The HUM and SOSC sequences are the heart of the Chicago core. People can choose from among 5-6 choices each for their HUM and SOSC sequences. The courses have somewhat different orientations. For instance, within SOSC, there are sequences oriented towards political philosophy, anthropology, sociology, and psychology. But all the HUM and SOSC courses have considerable overlaps in their syllabi, so that, just as at Columbia, there are a number of works that everyone in the College has studied fairly intensively, no matter which courses they chose. Everyone reads Adam Smith, Marx, Durkheim, Homer, Dante, Augustine, Genesis, Walter Benjamin, among others.
There are more choices for CIV (lots more) and Arts, and no real attempt at commonality there. Some Arts courses are more academic (e.g., an art history survey), others more about practice (e.g., studio drawing), and some combine the two. CIV courses tend to be intro area-studies surveys. Many of the quarter-abroad programs are designed to satisfy the CIV requirement through study about the history and culture of the host country.
In addition to the HUM-SOSC-CIV part of the core, students must take six courses in Biological Sciences, Physical Sciences, and Math. (As with HUM-Arts-CIV, you need at least two each of Bio and PhySci, but not necessarily sequential, and one Math.) There are special core courses available in Bio and PhySci for people who don’t want to take regular science courses, but the regular introductory curriculum in Biology, Physics, and Chemistry also satisfies the core requirement. The core gets satisfied by regular math classes at the level of regular calculus or above. Unlike in the other areas, the science/math core requirements can be satisfied in part with AP credits.
Finally, students are required to demonstrate competence in a foreign language at a level equivalent to a year of college study in that language. They can do it through AP/IB scores or passing a competency exam, or by taking and passing the appropriate college classes.
All of the HUM, SOSC, Arts, and Math classes, and many of the special core science classes, are taught in seminars of fewer than 20 students. Some courses are taught by tenured professors, some (but very few) by junior tenure-track faculty, many by recent PhDs hired just to teach core classes, and some by graduate students writing their dissertations. A single section taking a particular sequence may have different teachers each quarter or the same teacher; it varies a lot.