<p>Game design major here. I took Math 21. From bumping into some AMS10 sections in the computer lab, I can say that the content of the two classes is very similar. The big difference is that AMS10 uses Matlab, which isn’t useful to game design majors in my experience. Math 21 goes a bit deeper and covers more, from what I hear. If you intend to focus on graphics, you probably want to take Math 21, as you’ll need to be awesome at 3-D math (matricies).</p>