<p>Why study science at a LAC?</p>
<p>First, to be blunt, not all LACs have the same sophistication with the sciences as HC, so this can't be generalized. </p>
<p>Science is about mentorship and collaboration and this culture is HC's forte. Ariel Lowey, my research mentor, discovered factor 13 (the enzyme that cross-links blood clots and makes them insoluble) while at HC. I use to go over to his house 2x a year for dinner and we would also sometimes go to a local bar and have a beer as well. We'd talk about science, research but also politics and art. There's something very special with a young person having this kind of mentorship at a young age... to be listened to and respected... science is about nurturing new ideas and having a mentor-scientist like Ariel does that. It makes you fearless.</p>
<p>Haverford</a> biologist Andrea Morris is the first small college faculty member ever to win an NIH Career Development Award.</p>
<p>Steve E talks about Ariel
Haverford</a> College: Presidential Inauguration</p>
<p>Also, the most valuable tools you can bring to a science/medical career is not fact knowledge that only grow obsolete with time. The sciences at HC are very hands on and what is taught at a LAC (high volume work, research skills, writing skills, collaboration, analytical thinking, public speaking) is what is most important for a scientist. At large universities, most classes are taught in very large and anonymous lectures and are passive. By comparison, almost all of HC's sciences are in small seminar where students can ask questions, propose answers, work in small group and present research topics or have a lab component. Also, when visiting professors come to HC (no matter how famous), it is the undergrads who 1st have the floor to pose the questions... not grad students and not the faculty.</p>
<p>Not sure if I understand your other point about the senior tutorials. Bio 200provides an overview of molecular biology and basic lab techniques and junior year is spent acquiring more sophisticated lab experience and advanced bio knowledge. Senior year is spent applying what you have learned to a specific research project and attending visiting scholar seminars. I'm not sure what you find bad about this, it seems reasonable to me. The junior year seminars are pretty advanced and are taught senior year at large universities where there is less of a research component to occupy one's time senior year. Parts of bio 200 are taught junior year at many other lacs and universities.</p>
<p>I think not going to HC is a good choice for you. Not everyone learns the same way and not everyone values the same things in a college experience.</p>
<hr>
<p>301 Advanced Genetic Analysis NA
P.Meneely
The molecular mechanisms governing the transmission, mutation and expression of genes. Particular emphasis is placed on the use of experimental genetic methods to analyze other areas of biology. Prerequisite: Biology 200 or its equivalent or consent of instructor.</p>
<p>302 Cell Architecture NA
K.Johnson
An examination of cellular structure and function. Topics include the cytoplasmic matrix and the endomembrane system, with particular emphasis upon the dynamic qualities of living cells. Prerequisite: Biology 200 or its equivalent or consent of instructor.</p>
<p>303 Structure and Function of Macromolecules NA
R.Fairman
A study of the structure and function of proteins, including enzymes, assembly systems and proteins involved in interactions with nucleic acids and membranes. Prerequisite: Biology 200 and Chemistry 221 or equivalent to be taken previously or concurrently or consent of instructor.</p>
<p>304 Biochemistry: Metabolic Basis of Disease and Adaptation NA
J.Punt
This course will introduce students to advanced biosynthetic processes associated with carbohydrate, nucleic acid, protein and lipid metabolism. A coverage of the pathways and the experiments which defined them will be accompanied by discussions of their direct relevance to disease, abnormality and evolutionary adaptation. Prerequisite: Biology 200 and Chemistry 221 or equivalent to be taken previously or concurrently or consent of instructor.</p>
<p>306 Inter- and Intra-Cellular Communication NA
Staff
A study of the mechanisms by which individual cells in a multicellular organism communicate via the exchange of molecular signals. The course will focus on the release of "molecular messengers," their interactions with specific receptor-bearing target cells of appropriate responses such as increased metabolic activity and/or cell division. Considerable attention is paid to the biochemistry of plasma and internal cell membranes and pathways are discussed from a disease perspective. Prerequisite: Biology 200 or its equivalent or consent of instructor.
307 The Cell in Development NA
P.Meneely
The development of selected model organisms, both invertebrate and vertebrate, is used to examine the principles of fertilization, cleavage, gastrulation, morphogenesis, and pattern formation. Mechanisms by which genetic information is stored, segregated and activated during cell determination and differentiation are explored. Prerequisite: Biology 200 and 301 or consent of instructor.</p>
<p>308 Immunology NA
J.Owen
This course will provide an introduction to the rapidly expanding discipline of immunology. Students will learn about the molecular and cellular basis of the immune response through the study of the genetics and biochemistry of antigen receptors, the biochemistry of immune cell activation, the cell physiology of the immune system, immune memory, immune tolerance induction and immune-mediated cell death. Prerequisite: Biology 200 or consent of instructor.</p>
<p>309 Molecular Neurobiology NA
A.Morris
This course will focus on molecular approaches to study nervous system development, function and pathology. Topics including the generation of neurons and glia, electrical signaling, learning and memory and Alzheimer's disease will be discussed using examples from a variety of model systems. Prerequisite: Biology 200 or consent of instructor.</p>
<p>310 Molecular Microbiology NA
I.Okeke
A study of prokaryotic biology with emphasis on cell structure, gene organization and expressions, which will incorporate selected readings from the primary literature. Topics include the bacterial and viral cell structure, the genetics of bacteria and bacteriophage, gene regulation, horizontal gene transfer and microbial genomics. The course will be taught via lecture, class presentation and discussion, and workshops. Prerequisite: Biology 200 and Chem 221a or consent of the instructor.</p>
<p>312 Development & Evolution NA
R.Hoang
This course introduces important links between developmental and evolutionary biology. Genetic changes that produce variations between organisms are an important aspect of evolutionary change. Since development can be viewed as the process that links genetic information to the final form of an organism the fields of development and evolution clearly impact one another. We will look at Drosophila and zebrafish, where developmental mechanisms have been elucidated in remarkable detail. We will then look beyond these model systems to comparative studies that examine development in a range of organisms. We will consider how these comparative studies provide insight into evolutionary mechanisms and how underlying differences in development may account for the differences we see between organisms. Prerequisite: Biology 200 or consent of instructor.</p>
<p>330 Laboratory in Neural and Behavioral Science: Molecular Development NA
A.Morris
A half-semester lab course introducing molecular and cellular approaches to understanding the development of the nervous system. A variety of model organisms will be used to investigate neural induction, patterning, neural crest cell migration and axon guidance. Prerequisite: Biology 200 or consent of instructor.</p>
<p>ADVANCED HALF-SEMESTER COURSES IN MOLECULAR, CELLULAR, AND DEVELOPMENTAL BIOLOGY OF WHICH THREE OR FOUR ARE OFFERED IN ANY ONE YEAR</p>
<p>350 Pattern Formation in the Nervous System NA
A.Morris
A fundamental process in the development of the vertebrate nervous system is the partitioning of the nervous system into distinct domains of cellular differentiation, for example the brain vs. the spinal cord. This seminar course will explore, through a series of student research article presentations, the molecular processes by which pattern is established in the nervous system and the morphological consequences of improper patterning. Human birth defects and pathologies such as spina bifida and brain tumors will be used as case studies to discuss the role of crucial patterning genes and signaling molecules. Prerequisite: Biology 200 and 300b or consent of instructor.</p>
<p>351 Molecular Motors and Biological Nano-Machines NA
K. Johnson
The world of the cell contains a rich array of molecular machinery that carries out life's dynamic processes. Interdisciplinary studies of these mechanisms employing a variety of biological, chemical and physical approaches are revealing a wealth of detail spanning from visible phenomenon to the scale of atoms and molecules. Extensive reading of the primary literature will be used as a basis for student-led discussions. Topics will be selected from a list including viral assembly, cellular clocks, mechanoenzyme engines, biosynthetic machinery and the assembly and regulation of cytoskeletal arrays. These model systems provide novel insights into how work is accomplished (and regulated) in a nano-scale environment and serve as model systems for the development of microtechnologies for science and medicine. Prerequisite: Biology 302 or consent of instructor.</p>
<p>352 Cellular Immunology NA
J.Owen
Topics include description and classification of the cells and tissues of the immune system; cell collaboration in the immune response; transplantation antigens and their role in graft rejection and recognition of virally-infected cells; immune tolerance; lymphokines. There will be student presentations of articles in the original immunological literature, followed by critical discussion. Prerequisite: Biology 200 and 300b or consent of instructor.</p>
<p>353 Apoptosis: A Matter of Life and Death NA
J.Punt
Cell death is as important to an organism as cell differentiation and proliferation. In order to shape organs, limbs, and digits, form neural pathways, build a useful repertoire of specificities in the immune system, and start and stop inflammatory reactions, an organism needs to be able to regulate cell death via a highly regulated process we call apoptosis. A lack of regulation between cell death and proliferation underlies many disease states, including cancer and AIDS. In this course we will explore current advances in our understanding of the molecular basis for cell death (apoptosis), its regulation, its relationship to cell differentiation and proliferation, and its role in disease processes. The material will be presented in seminar format where primary literature will be read extensively and students will take the lead in the discussion and debate of current controversies. Prerequisite: Biology 200 and 300b or consent of instructor.</p>
<p>354 Computational Genomics NA
P.Meneely
Complete or nearly complete DNA sequences are available for the genomes of hundreds of species, including humans. Computer-based comparisons between DNA sequences of two different genes or two different species are now routinely used in biological research. This course will examine the biological and evolutionary basis of sequence comparisons, as well as introducing the students to the statistical foundations for such comparisons. The format will involve both lectures and in-class work done at the computer. Potential topics include: evolution of DNA sequences; pairwise comparison of two sequences or one sequence with a large number of sequences; alignment of sequences; identification of domains or motifs within proteins; gene structure identification from a DNA sequence; and a large scale genome comparisons. Prerequisite: Biology 301 or consent of instructor; Biology 303 recommended; student should be comfortable with statistical reasoning and high school algebra.</p>
<p>355 Signal Transduction and Cell Biology NA
J.Punt or J.Wagner
Seminar course that covers major areas of current interest in the field of cell signaling biochemistry and biology. Topics include: 1) cell surface receptor structure and function, 2) heterotrimeric and oncogenesis: covers present-day thinking on dysregulation of signaling pathways and how this leads to the development of various types of cancers. Prerequisite: Biology 200 and 300b or consent of instructor.</p>
<p>357 Protein Design NA
R.Fairman
This course will take a quantitative approach to the study of protein folding and protein structure using the primary research literature. We will particularly focus on these issues as they relate to function. Topics will include protein: DNA interactions, protein: protein interactions, and chaperones and their role in protein folding. Prerequisite: Biology 200 and 300b or consent of instructor.</p>
<p>358 Developmental Genetics NA
R.Hoang
This course will examine the structure of sex chromosomes, and how differences in sex chromosome constitution give rise to the familiar morphological differences between males and females. The emphasis will be on the genetic and molecular basis of sex determination, using the primary research literature. Model organisms will include invertebrates such as Caenorhabditis elegans and Drosophila melanogaster and vertebrates such as placental and non-placental mammals and reptiles. Prerequisite: Biology 301 or consent of instructor.</p>
<p>360 Bacterial Pathogenesis NA
I.Okeke
The course will begin with lectures to overview current concepts in bacterial pathogenesis. Initial readings will be taken from texts or reviews on the subject, and the rest of the course will consist of focused discussions on current research in the field and student presentations on the primary literature. Prerequisite: Biology 200 and 300b or consent of instructor.</p>