Can I take the Indian Institute of Tech ology entrance exam as an American Resident?

I am currently a high school senior in the US and I have applied to several colleges here. Since I am an Indian citizen, I am also quite interested in IIT. Is there any way I could apply from America?

Sounds like it, but you should contact them directly. A mention is made that Indian nationals in other countries are handled by the missions (embassy) in that country, so maybe start there.

https://www.thehindu.com/news/national/iits-to-hold-entrance-exam-abroad-for-foreign-students/article8264215.ece

https://www.ndtv.com/education/foreign-students-can-directly-take-jee-advanced-iit-entrance-exam-2108551