Pick the cheapest option. No one cares where their doctor went to medical school, even less where they did undergrad. Four years of tuition + fees at Penn will cost upwards of $350K.
Medical school debt can be crushing, especially because the loans become due as soon as you graduate. But your salary won’t be enough to make meaningful payments until you complete your residency. Many residents forbear their loans during residency. So a $350K loan can quickly balloon up to $500K+. This is a lot of debt to take on as you begin your life.
Doctors are well paid, but it makes no difference where you graduate from. Top students from Wayne State will be just as competitive as students from Penn for the best residencies.