<p>In the context of medical leave and otherwise "good" reasons? </p>
<p>I suppose it depends on your GPA and your reasons. If it is in an early semester, then it is probably not a big deal. If it is in one of your last two years, then you will have to explain convincingly that the reasons will not persist. You have given us very little information to go on.</p>
<p>How much is “huge”? I had 2 Ws on my transcript in the same semester, but it was explained by a medical issue and I didn’t have a problem getting into graduate programs. If you have all Ws in the same semester or clustered in the same year and it’s explainable by a resolved medical issue that no longer affects you - then shouldn’t be too much of an issue to explain, if you have an otherwise outstanding application. If you have Ws scattered throughout your years of college…that might be an issue.</p>