Most significant challenge application question

THE biggest challenge I ever faced was to do with health. But I’m not sure if it is fitting to the question, especially that my story doesn’t involve the “over coming the challenges” theme which I feel they are looking for. Is this a fitting topic for me to discuss? Or should I talk about other challenges (which in reality are less significant)?

If this challenge is the most significant to you, then by all means go for it! Perhaps instead of discussing how you overcame the challenge, talk about how you persisted in spite of everything and the ways in which it has challenged you to grow.