So I have this giant lecture hall class and I just don’t vibe with the people I sat next to randomly so if I move to another seat would it be awkward… this class have a few people who switch seats almost everyday or every week still…
Only if you make it awkward! Try sitting in a few different places 
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Just move to another seat, and don’t preemptively say anything to your seatmates. If you want to remove all possibility of awkwardness, move distinctly closer to the front or back so it looks like you moved to be closer/further to the professor.
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I like to sit away from everyone. There is only one professor whose lectures I sit as close as possible, no matter who I have to share space with.
If it’s a big lecture hall with plenty of empty seats, then change seats! I’m not in college (senior) but it’s not high school where there is a small classroom with a seating chart (hopefully) and every seat taken (hopefully)