Will a C+ in Sophomore year stop my chances of getting into good college?

I’m a sophomore and my current grades are

English // A
History // A
Pre-calculus // A-
Biology // A-
Japanese // A-
Chemistry // B-/C+

I am required to take Chemistry in sophomore year by my school but I want to enter a more english/history field for college. Will this hurt my chances of getting into a school like UCLA or NYU or a similar school?

These grades lower your GPA. The schools care about GPA. Therefore …

No one grade will stop your chances. Continue to work hard. You still have a long way to go before seeing what schools are a fit for you.