College Supplement Essay Typo

I was looking through my written supplement for a school (not the common app essay) and I noticed a typo - “The Oddysey” instead of “The Odyssey.” Other than that, the essay is flawless, with no other typos or other things spelled wrong. This is a very good school with around a 25% acceptance rate and I already passed in the application a couple of months ago. So, does this make a big difference in terms of my application?

No. And for reassurance, you can check the 25 million other threads asking the exact same question, including:
http://talk.qa.collegeconfidential.com/what-my-chances/470497-clam-fart-oh-my-god-what-did-i-do-p1.html