I can give you a bit of information as we have friends who went to both, and their children are currently attending (Loyola parents’ child attending Loyola, DePaul parents’ child attending DePaul).
Both have incredibly loyal and happy alumni. DePaul is located in Lincoln Park, which is an affluent area of the city, residential, fairly central and fairly easy to get to lots of stuff, including the lakeshore.
Loyola located north of the terminus of Lake Shore Drive. It is right near the lake, and also has a metro/el stop practically on its doorstep. It feels like a much more urban area of the city, the residential neighborhoods surrounding Loyola are a lot of apartments, and high-rises. It is closer to Evanston in some ways than to downtown Chicago, but as I said public transportation is quite close and easy to catch.
They each have a very different feel as campuses…I don’t know if you are planning on visiting in person, but if you can visit I would highly recommend doing so.
My friends who have children currently at both colleges are very happy with their children’s experiences. Though the son who started at Loyola last fall (entering class of 2024) did have rough adjustment with advising…it was fairly hands off and 1st semester was a bit overwhelming. He has since bounced back and is doing exceptionally well, and I don’t know if that is the norm (I wasn’t impressed by the advising story I was told), or if that was specific to it being Covid, advising being completely online, and a single less than ideal experience.
Child at DePaul really has loved her experience, she is in the honors program and raves about the opportunities she has gotten the last 3 years.
Loyola is near some good, local eating spots. There is a bit of a Chinatown outpost quite close, as well as some other very good options. Definitely some less gentrified areas close to Loyola as well, but well within what I would consider normal urban parameters.
If you have specific questions, please let me know…hope this was a little bit helpful.