Sorry, this got LONG!
I did a deep dive on IF when I started to see whether there was science behind the hoopla. What I found was that there was tons of science on mice and other animals but not on humans, though indications were good the benefits applied. Because I found a 16:8 IF so easy and similar to what I had been doing I stuck with it. I was amazed how the weight came off as I had been at essentially the same weight for a year. For me personally, I can say that all my bloodwork stayed the same or showed improvement except cholesterol. I’ve always been borderline on my cholesterol so I was bummed that the total number was higher but my ratio of HDL to LDL was still in the normal zone and had improved with a higher HDL, just like was mentioned in the Seattle Times story linked above.
The main thing I read about was autophagy. I’m not a doctor (and don’t play one on on cc) so I won’t try to explain it. Here’s an article from the Cleveland Clinic that explains it: Autophagy: Definition, Process, Fasting & Signs.
Like @sushiritto, I get regular DXA scans and after losing about 12 pounds on IF in four months (remember, this was after a YEAR at a plateau weight) two of those were of muscle, but that is similar to other chunks of weight loss I’ve had where a portion is muscle. I like lifting weights but don’t love it and should do more so I wasn’t surprised that I had lost some muscle. I blame me not IF for that. I should note that I haven’t changed what I’ve eaten. I’m not eating keto or paleo or whatever. I’m eating what I always have eaten, which has gotten “cleaner” over the years. Other than protein bars, I eat almost no processed foods. I used to be Queen of the Lean Cuisine. No more. And, yes, I did talk to my doctor about doing IF, and he was good.
The biggest difference I’ve seen in addition to the scale is where the weight has come off. I know you can’t spot reduce, but my torso/stomach has had the greatest loss, according to my DXA and the mirror. I’m an apple so that makes sense to me if autophagy is targeting fat cells. I may be misunderstanding the science and it’s all in my head – but at least it’s no longer on my gut so I am thrilled.
Here’s my bottom line: Could it be like Dumbo’s feather, and he just thinks that’s the reason he can fly or, in my case, lose weight? Sure. But it really is working for me. Here’s why I think it’s working for me – I am more likely to pass up an evening snack if I think I am going to counteract any autophageal effects of the past/future 24 hours. So, yes, I may be getting fewer calories, which, duh, leads to more weight loss, but I also am not eating closer to bed time, which if you’re a calories in/calories out person then that wouldn’t matter, right? I, personally, don’t believe it’s just about calories. We all know calories aren’t created equal. Like I said above, I sometimes used to eat two Lean Cuisines a day because they were calorie-controlled. But science tells us that processed foods affect obesity/belly fat. Once I cut those out two or three years ago I had another drop in weight.
A British documentarian taped a personal journey with IF that was a nice intro to the idea. I can post it if people want. I wasn’t sure whether it would violate TOS. Anyway, good luck if you decide to do it! I would discuss with your doctor. I know not everyone is on board with it. The nutritionist associated with my university-sponsored exercise class is not a fan, but in hearing her talk about it she points to extremes. I’m not doing anything remotely extreme, IMO. I’m just not snacking after an early dinner and holding off an hour or so for breakfast. No big deal to me, but it introduces a framework for my eating I didn’t have previously.