What are my chances?

Hi, I’m a high school senior who is conflicted about 2 schools. I have a 4.4 gpa weighted, 33 act, plenty of ecs and volunteer work. I want to apply ED2 to wake forest to wait to hear back from my EA schools. The problem is that I’m really struggling in AP Calc and will probably get a C for the semester. This would be my only C of high school. (I take all AP classes). Will I get deferred from Wake if they see a C on my transcript for 1st semester of senior year?

Wake Forest is extremely difficult to get into however they take a holistic view of the applicant. That being said I am not sure one “C” in AP calc will look bad. They value a strong academic course, good GPA and excellent essays and interview.
Clemson really looks at the GPA and test scores. In my opinion essays and interviews are less valued.
I have a son at Wake Forest and a daughter that was waitlisted at Clemson. His application experience was much more comprehensive than hers.